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Symbol
Name
ID 		Esr1
estrogen receptor 1 (alpha)
MGI:1352467
Phenotype annotations related to reproductive system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Prostate cancer
Disease(s) Associated with ESR1
prostate cancer

Mouse Phenotypes
reproductive system phenotype
ovary hemorrhage
detached sperm flagellum
oocyte degeneration
oligozoospermia
teratozoospermia
decreased male germ cell number
impaired granulosa cell differentiation
asthenozoospermia
abnormal prostate gland branching morphogenesis
abnormal seminal vesicle morphology
absent endometrial glands
decreased endometrial gland number
enlarged endometrial glands
abnormal ovary morphology
absent corpus luteum
decreased corpora lutea number
abnormal ovarian follicle morphology
abnormal granulosa cell morphology
absent mature ovarian follicles
abnormal ovarian follicle number
decreased primary ovarian follicle number
decreased primordial ovarian follicle number
increased tertiary ovarian follicle number
increased atretic ovarian follicle number
abnormal ovarian folliculogenesis
impaired ovarian folliculogenesis
abnormal tertiary ovarian follicle morphology
abnormal theca cell layer morphology
increased theca cell number
ovarian follicular cyst
ovary cyst
abnormal testis morphology
abnormal rete testis morphology
dilated rete testis
abnormal seminiferous tubule morphology
abnormal seminiferous tubule epithelium morphology
dilated seminiferous tubule
seminiferous tubule degeneration
abnormal testis weight
decreased testis weight
small testis
testicular atrophy
abnormal prostate gland physiology
uterus cyst
spermatic granuloma
early reproductive senescence
abnormal reproductive system morphology
abnormal female reproductive system morphology
abnormal uterus morphology
abnormal endometrium morphology
endometrium atrophy
endometrium hyperplasia
abnormal myometrium morphology
abnormal uterus development
abnormal uterus size
decreased uterus weight
increased uterus weight
enlarged uterus
small uterus
uterus hypoplasia
dilated uterus
abnormal vagina morphology
abnormal vagina epithelium morphology
vagina hypoplasia
abnormal spermatogenesis
abnormal male reproductive system morphology
abnormal internal male genitalia morphology
abnormal efferent ductules of testis morphology
dilated efferent ductule of testis
abnormal epididymis morphology
abnormal epididymis epithelium morphology
decreased epididymis weight
abnormal vas deferens morphology
early vaginal opening
abnormal reproductive system physiology
abnormal female reproductive system physiology
decreased superovulation rate
failure of superovulation
anovulation
decreased ovulation rate
abnormal estrous cycle
prolonged diestrus
short estrus
absent estrous cycle
failure of embryo implantation
abnormal uterine receptivity
abnormal uterus physiology
female infertility
reduced female fertility
decreased litter size
infertility
male infertility
reduced male fertility
impaired fertilization
abnormal male reproductive system physiology
failure of ejaculation
Availability Mouse Genotype
Esr1tm1.1Gust/Esr1tm1.1Gust
Esr1tm1.1Ics/Esr1tm1.1Ics *
Esr1tm1.1Mma/Esr1tm1.1Mma *
Esr1tm1.1Pws/Esr1tm1.1Pws
Esr1tm1Arnal/Esr1tm1Arnal
Esr1tm1Geog/Esr1tm1Geog
Esr1tm1Ksk/Esr1tm1Ksk
Esr1tm2.1Gsc/Esr1tm2.1Gsc
Esr1tm3.1Ksk/Esr1tm3.1Ksk
Esr1tm4.2Ksk/Esr1tm4.2Ksk
Esr1tm5.1Ksk/Esr1tm5.1Ksk
Esr1tm1.1Lja/Esr1+
Esr1tm1.1Lja/Esr1tm1.1Mma
Esr1tm1Ksk/Esr1+
Tg(MMTVtTA)1Mam/0
Tg(tetO-Esr1)#Paf/0
Esr1tm1.2Awo/Esr1tm1.2Awo
Tg(Cga-cre)1Awo/0  (conditional)		 *
Esr1tm1.2Awo/Esr1tm1.2Awo
Kiss1tm1.1(cre)Uboe/Kiss1+  (conditional)		 *
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Cga-cre)3Sac/0  (conditional)
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Cyp17a1-icre)AJako/0  (conditional)
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Wnt7a-EGFP/cre)#Bhr/0  (conditional)
Esr1tm1Gsc/Esr1tm1Gsc
Tg(Camk2a-cre)2Gsc/0  (conditional)
Esr1tm1Syeh/Esr1tm1Syeh
Tmem163Tg(ACTB-cre)2Mrt/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory